Active ingredientPolmacoxibCat. No. P-P152-001CAS 301692-76-2
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Impurity or related compound · Polmacoxib family
Pharmaceutical analytical standardPolmacoxib Methylthio Impurity
Synonyms: 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-methylsulfanylphenyl)furan-3-one
- Cat. No.
- P-P152-010
- CAS
- 301693-50-5
- Alternative CAS
- N/A
- Formula
- C19H17FO2S
- Molecular weight
- 328.40 g/mol
- Category
- Impurity or related compound
Family: Polmacoxib
A non-steroidal anti-inflammatory drug that inhibits COX-2 and also binds carbonic anhydrase, approved in South Korea in 2015 for the treatment of osteoarthritis.
Did you know?In the blood it concentrates in red blood cells, bound to carbonic anhydrase, which carry it in an inactive form; in inflamed joints, where this enzyme is scarce and COX-2 is abundant, it blocks inflammation.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Polmacoxib family
Active ingredientPolmacoxibCat. No. P-P152-001CAS 301692-76-2
Isotopically labelledPolmacoxib-d6Cat. No. P-P152-002
ImpurityPolmacoxib 2-Fluoro ImpurityCat. No. P-P152-003CAS 301693-28-7
ImpurityPolmacoxib Impurity 1Cat. No. P-P152-004
ImpurityPolmacoxib Impurity 2Cat. No. P-P152-005
ImpurityPolmacoxib Impurity 3 Sodium SaltCat. No. P-P152-006CAS 1778703-67-5
ImpurityPolmacoxib Impurity 4Cat. No. P-P152-007
ImpurityPolmacoxib Impurity 5Cat. No. P-P152-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.