Active ingredientPonatinibCat. No. P-P156-001CAS 943319-70-8
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Metabolite · Ponatinib family
Pharmaceutical analytical standardPonatinib Metabolite AP-24567
Synonyms: Benzamide, 3-(2-imidazo(1,2-b)pyridazin-3-ylethynyl)-4-methyl-N-(4-(1-piperazinylmethyl)-3-(trifluoromethyl)phenyl)-, Ponatinib N-Desmethyl Analog
- Cat. No.
- P-P156-003
- CAS
- 943319-87-7
- Alternative CAS
- 2941512-87-2 (hydrochloride)
- Formula
- C28H25F3N6O
- Molecular weight
- 518.54 g/mol
- Category
- Metabolite
Family: Ponatinib
A third-generation tyrosine kinase inhibitor for chronic myeloid leukaemia and Philadelphia chromosome-positive acute lymphoblastic leukaemia, approved in the United States in December 2012.
Did you know?It was developed to hit the T315I mutation too, which makes the BCR-ABL protein resistant to other inhibitors: a slender, linear carbon-carbon triple bond lets it avoid the bulk of the mutated amino acid.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ponatinib family
Active ingredientPonatinibCat. No. P-P156-001CAS 943319-70-8
Active ingredientPonatinib HydrochlorideCat. No. P-P156-002CAS 1114544-31-8
MetabolitePonatinib Metabolite AP-24600Cat. No. P-P156-004CAS 1300690-48-5
MetabolitePonatinib N-beta-D-GlucuronideCat. No. P-P156-005
Isotopically labelledPonatinib-d8Cat. No. P-P156-006CAS 1562993-37-6
NitrosamineN-Nitroso Ponatinib Metabolite AP-24567Cat. No. P-P156-007
ImpurityPonatinib Impurity 1Cat. No. P-P156-008
ImpurityPonatinib Impurity 2Cat. No. P-P156-009CAS 694499-26-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.