Active ingredientPosaconazoleCat. No. P-P159-001CAS 171228-49-2
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Impurity or related compound · Posaconazole family
Pharmaceutical analytical standardPosaconazole Impurity 28
Synonyms: 1-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]-4-nitrosopiperazine
- Cat. No.
- P-P159-059
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C24H26F2N6O3
- Molecular weight
- 484.51 g/mol
- Category
- Impurity or related compound
Family: Posaconazole
A triazole antifungal approved in Europe in 2005, active even against difficult moulds such as Aspergillus and the Mucorales. It is used above all to protect patients with very weak immune defences from fungal infections.
Did you know?The first formulation, an oral suspension, has to be taken with a high-fat meal: food increases its absorption several times over.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Posaconazole family
Active ingredientPosaconazoleCat. No. P-P159-001CAS 171228-49-2
MetabolitePosaconazole-D-GlucuronideCat. No. P-P159-002CAS 697751-82-9
Isotopically labelledPosaconazole-d5Cat. No. P-P159-004CAS 1217785-83-5
NitrosamineN-Nitroso Posaconazole Impurity 1Cat. No. P-P159-005
ImpurityPosaconazole Impurity 1Cat. No. P-P159-006CAS 156570-10-4
Impurity1-(4-Hydroxyphenyl)piperazineCat. No. P-P159-007CAS 56621-48-8
ImpurityPosaconazole Impurity 2Cat. No. P-P159-008CAS 122151-32-0
ImpurityPosaconazole Impurity 3Cat. No. P-P159-009CAS 170985-85-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.