Active ingredientPromethazineCat. No. P-P209-001CAS 60-87-7
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Active ingredient · Promethazine family
Pharmaceutical analytical standardPromethazine Hydrochloride
Synonyms: Remsed, Diprasine, Fellozine, Promethacon, Promethegan, Ganphen, Plletia, Prometh Fortis, Prometh Plain, Mymethazine Fortis, Kinetosin, Promantine, Phencen, Primine, Dorme, Prorex, Genphen, N-(2-Dimethylaminopropyl-1)phenothiazine hydrochloride, N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine hydrochloride, Phenothiazine, 10-(2-(dimethylamino)propyl)-, monohydrochloride, Sarantihist, Phenhalal, Q-mazine, Phenergan nightime, V-Gan, Anergan, Phenergan, N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride, Fenergan, Pipolfen, Pipolphen, Romergan, Promethiazin, Lergigan, Avomine, Allerfen, Duplamin, Frinova, Goodnight, Hibechin, Histantil, Phenadoz, Proneurin, Soporil, Bonnox, Closin, Prome, Eusedon Mono, Phenergan Fortis, Phenergan plain, Phenergan hydrochloride, Phanergan D, Component of Mepergan, Phenothiazine, 10-(2-(dimethylamino)-propyl)-, hydrochloride, N-(2'-Dimethylamino-2'-methylaethyl)-phenothiazin hydrochlorid, N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine hydrochloride, N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine--hydrogen chloride (1/1)
- Cat. No.
- P-P209-002
- CAS
- 58-33-3
- Alternative CAS
- 60-87-7 (free base)
- 17693-51-5 (other salt)
- Formula
- C17H20N2S·HCl
- Molecular weight
- 320.88 g/mol
- Category
- Active ingredient (API)
Family: Promethazine
An antihistamine of the phenothiazine family, synthesised in France in the 1940s: besides allergies it is used against nausea, vomiting and motion sickness, and as a sedative.
Did you know?The same line of research, led in both cases by chemist Paul Charpentier, produced chlorpromazine in 1950, the first antipsychotic to reach the market, which changed the history of psychiatry.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Promethazine HydrochlorideBP 412
- Promethazine for peak identification CRSEP Y0000797
- Promethazine hydrochloride CRSEP P3400000
More products in the Promethazine family
Active ingredientPromethazineCat. No. P-P209-001CAS 60-87-7
Pharmacopoeial impurityPromethazine EP Impurity B HydrochlorideCat. No. P-P209-003CAS 5568-90-1
Pharmacopoeial impurityPromethazine EP Impurity C HydrochlorideCat. No. P-P209-004CAS 60113-77-1
Pharmacopoeial impurityPromethazine EP Impurity DCat. No. P-P209-005CAS 7640-51-9
MetabolitePromethazine-N-Glucuronide (Mixture of Diastereomers)Cat. No. P-P209-006
Isotopically labelledPromethazine EP Impurity D-d6Cat. No. P-P209-007CAS 1189892-93-0
Isotopically labelledPromethazine-d4 HydrochlorideCat. No. P-P209-008CAS 1173018-74-0
Isotopically labelledPromethazine-d6 HydrochlorideCat. No. P-P209-009CAS 1189947-02-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.