Isotopically labelledPropylthiouracil-d5Cat. No. P-P222-002CAS 1189423-94-6
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Active ingredient · Propylthiouracil family
Pharmaceutical analytical standardPropylthiouracil
Synonyms: 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one, Propacil, Procasil, Propycil, Prothyran, Prothiurone, Thiuragyl, Prothiucil, Protiural, Prothycil, Propyl-Thiorist, Propyl-Thyracil, Thyreostat II, Propylthiorit, Propythiouracil, Propilthiouracil, Propiltiouracilo, Propiltiouracile, NSC 6498, NSC 70461, PTU (thyreostatic), Uracil, 6-propyl-2-thio-, Propyl-Thi, Pharmakon1600-01500515, NSC 757302
- Cat. No.
- P-P222-001
- CAS
- 51-52-5
- Alternative CAS
- 59889-81-5 (sodium salt)
- 500-50-5 (alternative CAS, same compound)
- Formula
- C7H10N2OS
- Molecular weight
- 170.23 g/mol
- Category
- Active ingredient (API)
A thiouracil-derived antithyroid drug, approved in the United States in 1947: it blocks thyroid peroxidase, the enzyme that makes thyroid hormones, and reduces the conversion of T4 into the more active T3. It is used for hyperthyroidism, for example in Graves' disease.
Did you know?It tastes bitter, like phenylthiocarbamide (PTC), but not everyone perceives it in the same way: sensitivity to this taste appears to be genetic.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Propylthiouracil CRSEP P3700000
More products in the Propylthiouracil family
Isotopically labelledPropylthiouracil-d5Cat. No. P-P222-002CAS 1189423-94-6
Impurity6-PropyluracilCat. No. P-P222-003CAS 13345-08-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.