Active ingredient · Pyrathiazine family
Pharmaceutical analytical standardPyrathiazine Hydrochloride
Synonyms: 10H-Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-, hydrochloride (1:1), Rolazote, Pyrrolazote, Pyrrolazote abergic, N-(2-Pyrrolidinoethyl)phenothiazine hydrochloride, Parathiazine hydrochloride, Pyrrolazote hydrochloride, Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-, monohydrochloride
- Cat. No.
- P-P236-001
- CAS
- 522-25-8
- Alternative CAS
- 84-08-2 (free base)
- Formula
- C18H20N2S·HCl
- Molecular weight
- 332.89 g/mol
- Category
- Active ingredient (API)
A phenothiazine derivative, chemically 10-[2-(1-pyrrolidinyl)ethyl]phenothiazine, of the same chemical family as the antihistamine promethazine: in the late 1940s it was evaluated clinically in the treatment of allergic diseases.
Did you know?Its core, phenothiazine, was first prepared in 1883 by Heinrich August Bernthsen by reacting diphenylamine with sulphur; one of its derivatives, the dye methylene blue, had already existed since 1876.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
Shipped under controlled temperature when the molecule requires it.
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Sent with every order.
Follow your shipment live, from our warehouse to your lab.
Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.