Active ingredientRanolazineCat. No. P-R015-001CAS 95635-55-5
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Impurity or related compound · Ranolazine family
Pharmaceutical analytical standardRanolazine Impurity 9
Synonyms: Ranolazine N-Oxide, Ranolazine 4-N-Oxide, Ranolazine piperazine 1-oxide
- Cat. No.
- P-R015-036
- CAS
- 2725395-82-2
- Alternative CAS
- N/A
- Formula
- C24H33N3O5
- Molecular weight
- 443.54 g/mol
- Category
- Impurity or related compound
Family: Ranolazine
A piperazine-derived antianginal, approved in the United States in 2006 and in Europe in 2008 for chronic stable angina: it inhibits the late sodium current in heart cells, preventing calcium overload.
Did you know?Unlike many antianginals, its action does not depend on slowing the pulse or lowering blood pressure: in studies these fell on average by less than 2 beats per minute and less than 3 mmHg.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ranolazine family
Active ingredientRanolazineCat. No. P-R015-001CAS 95635-55-5
Pharmacopoeial impurityRanolazine USP Related Compound ACat. No. P-R015-002CAS 2210-74-4
Pharmacopoeial impurityRanolazine USP Related Compound B (Free Form)Cat. No. P-R015-003CAS 755711-09-2
Pharmacopoeial impurityRanolazine USP Related Compound B DiHClCat. No. P-R015-004CAS 95635-61-3
Pharmacopoeial impurityRanolazine USP Related Compound CCat. No. P-R015-005CAS 5294-61-1
Pharmacopoeial impurityRanolazine USP Related Compound DCat. No. P-R015-006CAS 380204-72-8
MetaboliteRanolazine glucuronideCat. No. P-R015-007
Isotopically labelledRanolazine-d3Cat. No. P-R015-008CAS 1054624-77-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.