Active ingredient · Raubasine family
Pharmaceutical analytical standardRaubasine
Synonyms: Ajmalicine, delta-Yohimbine, Tetrahydroserpentine, Ajmalicin, Circolene, Sarpan, Hydrosarpan, Rauvasan, Isoarteril, NSC 72133, Methyl (1S,15R,16S,20S)-16-methyl-17-oxa-3,13-diazapentacyclo(11.8.0.02,10.04,9.015,20)henicosa-2(10),4,6,8,18-pentaene-19-carboxylate, Substance II, Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methylester, (19a)-, Methyl (19alpha)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate, Ajmalicina, Cristanyl, Rauwolfia alkaloid, Lamuran, Alkaloids, Rauwolfia, Pytetrahydroserpentine, Methyl (19-methyl-16,17-dehydro-18-oxa-3alpha,15alpha,19beta,20beta-yohimban-16-carboxylat), Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19-alpha)-, Methyl (19alpha)-19-methyl-16,17-didehydrooxayohimban-16-carboxylate
- Cat. No.
- P-R018-001
- CAS
- 483-04-5
- Alternative CAS
- 4373-34-6 (hydrochloride)
- 8063-17-0 (alternative CAS, same compound)
- Formula
- C21H24N2O3
- Molecular weight
- 352.43 g/mol
- Category
- Active ingredient (API)
An indole alkaloid, also known as ajmalicine, found in various Rauvolfia species, in the Madagascar periwinkle (Catharanthus roseus) and in Mitragyna speciosa: it blocks alpha-1 adrenergic receptors and is used as an antihypertensive.
Did you know?It was among the alkaloids extracted from the roots of Rauvolfia serpentina by the chemist Salimuzzaman Siddiqui, who in 1931 had isolated ajmaline, naming it after his mentor Hakim Ajmal Khan.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
Shipped under controlled temperature when the molecule requires it.
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Sent with every order.
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Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
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