Active ingredientRilpivirineCat. No. P-R059-001CAS 500287-72-9
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Impurity or related compound · Rilpivirine family
Pharmaceutical analytical standardRilpivirine Impurity 1 Hydrochloride
Synonyms: (2E)-3-(4-Amino-3,5-dimethylphenyl)prop-2-enenitrile Hydrochloride, Rilpivirine Nitrile Impurity
- Cat. No.
- P-R059-009
- CAS
- 661489-23-2
- Alternative CAS
- 500292-94-4 (free base)
- Formula
- C11H13ClN2
- Molecular weight
- 208.69 g/mol
- Category
- Impurity or related compound
Family: Rilpivirine
A non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV, approved in the United States in 2011. It is used in combination with other antiretrovirals, including in single tablets that combine several active ingredients.
Did you know?Together with cabotegravir, in 2021 it became part of the first complete long-acting HIV regimen approved in the United States: periodic intramuscular injections instead of daily tablets.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Rilpivirine family
Active ingredientRilpivirineCat. No. P-R059-001CAS 500287-72-9
Active ingredientRilpivirine HydrochlorideCat. No. P-R059-002CAS 700361-47-3
MetaboliteRilpivirine N-GlucuronideCat. No. P-R059-003CAS 1437791-52-0
Isotopically labelledRilpivirine-D6Cat. No. P-R059-004CAS 1312424-26-2
NitrosamineN,N-Di-Nitroso RilpivirineCat. No. P-R059-006
NitrosamineN2-Nitroso RilpivirineCat. No. P-R059-007
NitrosamineN4-Nitroso RilpivirineCat. No. P-R059-008
ImpurityRilpivirine Impurity 2Cat. No. P-R059-010CAS 1009330-41-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.