ImpurityRitlecitinib Dimer ImpurityCat. No. P-R069-002CAS 2374827-88-8
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Active ingredient · Ritlecitinib family
Pharmaceutical analytical standardRitlecitinib
- Cat. No.
- P-R069-001
- CAS
- 1792180-81-4
- Alternative CAS
- 2192215-81-7 (other form)
- Formula
- C15H19N5O
- Molecular weight
- 285.35 g/mol
- Category
- Active ingredient (API)
An oral inhibitor of JAK3 and the TEC kinase family, approved in June 2023 in the United States and in September 2023 in the European Union for severe alopecia areata, in adults and adolescents aged 12 and over.
Did you know?It binds covalently and irreversibly to a cysteine at position 909 of JAK3; the TEC family kinases have the same cysteine at the equivalent position, which is why it blocks both.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ritlecitinib family
ImpurityRitlecitinib Dimer ImpurityCat. No. P-R069-002CAS 2374827-88-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.