Active ingredientRitonavirCat. No. P-R071-001CAS 155213-67-5
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Pharmacopoeial impurity · Ritonavir family
Pharmaceutical analytical standardRitonavir EP Impurity U
Synonyms: Ritonavir Impurity U
- Cat. No.
- P-R071-055
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C51H69N9O7S3
- Molecular weight
- 1016.35 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Ritonavir
An HIV protease inhibitor approved in the US in 1996; by slowing a cytochrome P450 liver enzyme it is also used as a booster for other drugs, for example with nirmatrelvir against COVID-19.
Did you know?In 1998, two years after approval, a new and far less soluble crystal form suddenly appeared, form II: it has been the textbook case of drug polymorphism ever since.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
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Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.