Active ingredientSarizotan DiHClCat. No. P-S017-001CAS 177976-12-4
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Impurity or related compound · Sarizotan family
Pharmaceutical analytical standardSarizotan Impurity 2
Synonyms: [(2R)-3,4-Dihydro-2H-chromen-2-yl]methanamine
- Cat. No.
- P-S017-006
- CAS
- 404337-71-9
- Alternative CAS
- 437763-66-1 (hydrochloride)
- Formula
- C10H13NO
- Molecular weight
- 163.22 g/mol
- Category
- Impurity or related compound
Family: Sarizotan
An investigational compound, a serotonin 5-HT1A receptor agonist and D2 receptor antagonist: it was studied for levodopa-induced dyskinesia in Parkinson's disease and then for breathing problems in Rett syndrome, and its development ended in 2020 without approval.
Did you know?In mouse models of Rett syndrome it cut apnoea by about 75 to 80% and corrected irregular breathing, making up for the brain serotonin deficit also seen in people with this syndrome.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Sarizotan family
Active ingredientSarizotan DiHClCat. No. P-S017-001CAS 177976-12-4
NitrosamineN-Nitroso SarizotanCat. No. P-S017-002
ImpuritySarizotan Impurity 1Cat. No. P-S017-003CAS 177976-33-9
Impurity5-(4-Fluorophenyl)-3-pyridinemethanolCat. No. P-S017-004CAS 222551-22-6
Impurityent-Sarizotan DiHClCat. No. P-S017-005CAS 177976-13-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.