Active ingredientSelexipagCat. No. P-S027-001CAS 475086-01-2
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Impurity or related compound · Selexipag family
Pharmaceutical analytical standardSelexipag Impurity 9
Synonyms: N-[4-(5,6-Diphenylpyrazin-2-yl)oxybutyl]-5,6-diphenylpyrazin-2-amine
- Cat. No.
- P-S027-026
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C36H31N5O
- Molecular weight
- 549.68 g/mol
- Category
- Impurity or related compound
Family: Selexipag
A selective prostacyclin IP receptor agonist taken by mouth: it widens the arteries of the lungs and curbs platelet aggregation. Approved in the United States in 2015 and in Europe in 2016 for pulmonary arterial hypertension.
Did you know?Prostacyclin and its analogues last too briefly in the blood for convenient use; selexipag, a diphenylpyrazine derivative that looks nothing like it, mimics its action and in the body becomes a metabolite 37 times more potent.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Selexipag family
Active ingredientSelexipagCat. No. P-S027-001CAS 475086-01-2
MetaboliteSelexipag Metabolite N-OxideCat. No. P-S027-002CAS 2732400-56-3
Isotopically labelledSelexipag Metabolite-d6Cat. No. P-S027-003CAS 1265295-56-4
Isotopically labelledSelexipag-d6Cat. No. P-S027-004CAS 1265295-92-8
Isotopically labelledSelexipag-d8Cat. No. P-S027-005CAS 1265295-16-6
NitrosamineN-Nitroso Selexipag Impurity 1Cat. No. P-S027-006
NitrosamineN-Nitroso Selexipag Impurity 2Cat. No. P-S027-007
NitrosamineN-Nitroso Selexipag Impurity 3Cat. No. P-S027-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.