Active ingredientSerineCat. No. P-S033-001CAS 56-45-1
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Pharmacopoeial impurity · Serine family
Pharmaceutical analytical standardSerine EP Impurity C
Synonyms: L-Histidine, Histidine, Histidina, Istidina, L-Histidin, Histidine, l-, L-His, FEMA No. 3694, Histidinum, NSC 137773, L-isomer Histidine, L-Histidine High, alpha-Amino-1H-imidazole-4-propionic acid, L-Histidine 7409, L-Histidine High 7410, H-His-OH, S-Histidine, L-beta-(4-Imidazolyl)-alpha-alanin, L-beta-(4-Imidazolyl)alanin, L-Alanine, 3-(1H-imidazol-4-yl)-, Histidine (USP/INN), Histidine (L-Histidine), alpha-Amino-1H-imidazole-4-propionic acid, (S)-, L-Histidine, non-animal source, Histidine (mart.), L-hystidine, L-Hisidine, L-Histidine (TF), L-His-OH, L-Histidine (JP18), L-Histidine (H-His-OH), Imidazole C-4(5) deriv. 5
- Cat. No.
- P-S033-018
- CAS
- 71-00-1
- Alternative CAS
- N/A
- Formula
- C6H9N3O2
- Molecular weight
- 155.16 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Serine
A non-essential amino acid that the body can make itself: it is a building block of proteins and the starting point for glycine, cysteine and sphingolipids; in the brain its D form acts as a neuromodulator of NMDA receptors.
Did you know?Its name comes from the Latin sericum, silk: it was first obtained in 1865 by the chemist Emil Cramer from silk proteins, which are particularly rich in it.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Histidine CRSEP H0750000
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Active ingredientSerineCat. No. P-S033-001CAS 56-45-1
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Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.