Active ingredientSotalolCat. No. P-S069-001CAS 3930-20-9
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Pharmacopoeial impurity · Sotalol family
Pharmaceutical analytical standardSotalol EP Impurity A
Synonyms: Deoxysotalol, N-[4-[2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide, Methanesulfonamide, N-(4-(2-((1-methylethyl)amino)ethyl)phenyl)-, N-(4-(2-(isopropylamino)ethyl)phenyl)methanesulfonamide
- Cat. No.
- P-S069-003
- CAS
- 16974-42-8
- Alternative CAS
- 16974-44-0 (hydrochloride)
- Formula
- C12H20N2O2S
- Molecular weight
- 256.36 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Sotalol
A non-selective beta-blocker with an added class III antiarrhythmic action, studied since the 1960s; it is used against various ventricular and supraventricular arrhythmias, including to maintain normal rhythm after atrial fibrillation.
Did you know?It is a mixture of two mirror-image forms: almost all the beta-blocking effect comes from the levorotatory form, while both lengthen the heart's action potential equally.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Sotalol family
Active ingredientSotalolCat. No. P-S069-001CAS 3930-20-9
Active ingredientSotalol HydrochlorideCat. No. P-S069-002CAS 959-24-0
Pharmacopoeial impuritySotalol EP Impurity A HydrochlorideCat. No. P-S069-004CAS 16974-44-0
Pharmacopoeial impuritySotalol EP Impurity B HydrochlorideCat. No. P-S069-005CAS 5576-49-8
Pharmacopoeial impuritySotalol EP Impurity CCat. No. P-S069-006CAS 83922-54-7
Pharmacopoeial impuritySotalol EP Impurity DCat. No. P-S069-007CAS 2724689-38-5
Pharmacopoeial impuritySotalol EP Impurity D HCl SaltCat. No. P-S069-008CAS 2724689-39-6
Isotopically labelledN-Nitroso Sotalol-d6Cat. No. P-S069-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.