Metabolite(2S)-2-Hydroxy TasimelteonCat. No. P-T018-002CAS 1448344-05-5
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Active ingredient · Tasimelteon family
Pharmaceutical analytical standardTasimelteon
Synonyms: Hetlioz, Hetlioz lq, N-((2-(2,3-dihydro-4-benzofuranyl)cyclopropyl)methyl)propanamide, N-(((1R,2R)-2-(2,3-Dihydro-1-benzofuran-4-yl)cyclopropyl)methyl)propanamide, N-(((1R,2R)-2-(2,3-dihydrobenzofuran-4-yl)cyclopropyl)methyl)propionamide, Propanamide, N-(((1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl)methyl)-
- Cat. No.
- P-T018-001
- CAS
- 609799-22-6
- Alternative CAS
- N/A
- Formula
- C15H19NO2
- Molecular weight
- 245.32 g/mol
- Category
- Active ingredient (API)
A melatonin MT1 and MT2 receptor agonist, approved in the United States in 2014 for non-24-hour sleep-wake disorder and in 2020 for night-time sleep disturbances in Smith-Magenis syndrome.
Did you know?According to the FDA it was the first treatment approved for non-24-hour disorder, in which the body clock does not keep in step with the day; in Europe it is indicated for totally blind adults.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Tasimelteon family
Metabolite(2S)-2-Hydroxy TasimelteonCat. No. P-T018-002CAS 1448344-05-5
Metabolite(3R)-3-Hydroxy TasimelteonCat. No. P-T018-003CAS 1448344-01-1
Metabolite(3S)-3-Hydroxy TasimelteonCat. No. P-T018-004CAS 1448344-03-3
Metabolite2-Hydroxy Tasimelteon O-GlucuronideCat. No. P-T018-005
MetaboliteTasimelteon N-GlucuronideCat. No. P-T018-006
Isotopically labelledTasimelteon-d5Cat. No. P-T018-007CAS 1962124-51-1
NitrosamineN-Nitroso TasimelteonCat. No. P-T018-008
ImpurityTasimelteon Impurity 1Cat. No. P-T018-009CAS 1803286-27-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.