Pharmacopoeial impurityTheophylline EP Impurity BCat. No. P-T084-002CAS 1076-22-8
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Active ingredient · Theophylline family
Pharmaceutical analytical standardTheophylline
Synonyms: 1,3-dimethyl-7H-purine-2,6-dione, Elixophyllin, Theolair, Nuelin, Elixophylline, Lanophyllin, Respbid, Solosin, Theocin, Theo-dur, Liquophylline, Optiphyllin, Parkophyllin, Theofol, Theograd, Acet-theocin, Slo-phyllin, Armophylline, Slo-bid, Doraphyllin, Elixicon, Maphylline, Medaphyllin, Teofyllamin, Theacitin, Theocontin, Theovent, Uniphyllin, Xantivent, Austyn, Elixex, Teolair, Uniphyl, Accurbron, Aerolate III, Bronkodyl, Euphylong, Theophyl-225, Aerolate, Duraphyl, Theobid, Quibron T/SR, Sustaire, Teofilina, Theochron, Asmax, Somophyllin-t, Bronkodyl SR, Constant-T, Theoclair-SR, Theoclear LA, Quibron-T, Spophyllin retard, Theophyline, Theoclear 80, Theodel, Theostat 80, Theona P, Synophylate-L.A. Cenules, Theo-Dur-Sprinkle, Aquaphyllin, Elixomin, Theolixir, Theophyl, LaBID, Elixophyllin SR, LASMA, Pro-vent, Somophyllin-CRT, Aerolate SR, Theophyl-SR, Uni-Dur, T-Phyl, Theoclear-200, Theolair-SR, Nuelin SA, Theobid Jr., Uniphyllin continus, Theoclear L.A.-130, Xanthine, 1,3-dimethyl-, NSC 2066, Quibron, Doxophylline metabolite m3, Aerolate jr, Theoclear-100, Theoclear l.a.-260, Theobid Duracap, Theodur G, NSC 757346, ct, theo von, Von ct, theo, Senophylline, Nuelin sa-250, Theophyllinate, Glycine, Theolix, Choledyl SA, Theospan, Aerobin, Tefamin, Theopek, Unifyl, Euphylline, Bronkotabs, Theo-Organidin, Theal tabl., Duraphyllin, Diffumal, Teonova, Mudrane, Pulmidur, Theokin, Hylate, Bronchodid Duracap, Telbans, Physpa, Unicontin CR, Aescin-IIA, Component of Primatene, Xanthine,3-dimethyl-, Component of Theo-Organidin, Component of Dicurin Procaine, Pharmakon1600-01500568
- Cat. No.
- P-T084-001
- CAS
- 58-55-9
- Alternative CAS
- 317-34-0 (other salt)
- 75448-53-2 (alternative CAS, same compound)
- 49746-06-7 (alternative CAS, same compound)
- 50857-74-4 (alternative CAS, same compound)
- 8061-56-1 (alternative CAS, same compound)
- Formula
- C7H8N4O2
- Molecular weight
- 180.17 g/mol
- Category
- Active ingredient (API)
A methylxanthine related to caffeine, first extracted from tea leaves in 1888 by German biochemist Albrecht Kossel: since the 1920s it has been used as a bronchodilator for asthma and COPD.
Did you know?Its name means tea leaf (from Thea, the old genus name for tea, and the Greek phyllon, leaf), yet brewed tea contains only traces of it: about 1 mg per litre.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- TheophyllineBP 327
- Theophylline CRSEP T0800000
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NitrosamineN-Nitroso TheophyllineCat. No. P-T084-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.