Active ingredientThiamazoleCat. No. P-T085-001CAS 60-56-0
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Pharmacopoeial impurity · Thiamazole family
Pharmaceutical analytical standardThiamazole EP Impurity A
Synonyms: Methimazole USP Related Compound A, 2,2-Dimethoxyethylmethylamine, 2,2-dimethoxy-N-methylethanamine, Methylaminoacetaldehyde dimethyl acetal, Ethanamine, 2,2-dimethoxy-N-methyl-, N-Methylaminoacetaldehyde dimethyl acetal, Acetaldehyde, (methylamino)-, dimethyl acetal, NSC 66270, N-(2,2-dimethoxyethyl)-N-methylamine, Methyl(2,2-dimethoxyethyl)amine, Sarcosinal dimethyl acetal, Thiamazole impurity a (ep impurity), N-(2,2-Dimethoxyethyl)methylamine, N-Methyl-2,2-dimethoxyethanamine, Ethanamine,2-dimethoxy-N-methyl-, N-(2,2-dimethoxyethyl)methanamine, N-Methyl-N-2,2-dimethoxyethylamine
- Cat. No.
- P-T085-002
- CAS
- 122-07-6
- Alternative CAS
- 56766-80-4 (hydrochloride)
- Formula
- C5H13NO2
- Molecular weight
- 119.16 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Thiamazole
An antithyroid drug of the thionamide class, also known as methimazole, which reduces thyroid hormone production; in use since the late 1940s against hyperthyroidism, for example in Graves' disease.
Did you know?Antithyroid drugs were born in 1943, when endocrinologist Edwin Astwood published the first treatments of hyperthyroidism with thiourea and thiouracil; in 1949 Astwood himself studied methimazole.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Thiamazole impurity A CRSEP Y0000372
More products in the Thiamazole family
Active ingredientThiamazoleCat. No. P-T085-001CAS 60-56-0
Pharmacopoeial impurityThiamazole EP Impurity A HydrochlorideCat. No. P-T085-003CAS 56766-80-4
Pharmacopoeial impurityThiamazole EP Impurity BCat. No. P-T085-004CAS 616-47-7
Pharmacopoeial impurityThiamazole EP Impurity CCat. No. P-T085-005CAS 14486-52-3
Pharmacopoeial impurityThiamazole EP Impurity C HydrochlorideCat. No. P-T085-006CAS 858220-92-5
MetaboliteThiamazole Thio-beta-D-glucuronideCat. No. P-T085-007CAS 39038-19-2
Isotopically labelledThiamazole-d3Cat. No. P-T085-008CAS 1160932-07-9
NitrosamineN-Nitroso ThiamazoleCat. No. P-T085-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.