Pharmacopoeial impurityTibolone EP Impurity ACat. No. P-T111-002CAS 105186-35-4
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Active ingredient · Tibolone family
Pharmaceutical analytical standardTibolone
Synonyms: Liviella, Livial, Org OD 14, Xyvion, NSC 759898, Tibilone, Boltin, Tibofem
- Cat. No.
- P-T111-001
- CAS
- 5630-53-5
- Alternative CAS
- N/A
- Formula
- C21H28O2
- Molecular weight
- 312.45 g/mol
- Category
- Active ingredient (API)
A synthetic steroid with weak oestrogenic, progestogenic and androgenic activity, developed in the 1960s and introduced in the Netherlands in 1988: it is used in menopausal hormone therapy and against postmenopausal osteoporosis.
Did you know?In the body it turns into metabolites with different actions: two hydroxy derivatives act as oestrogens, while delta-4-tibolone has progestogenic and androgenic effects.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- TiboloneBP 848
- Tibolone CRSEP Y0002348
- Tibolone for system suitability CRSEP Y0000668
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ImpurityTibolone Impurity 1Cat. No. P-T111-009CAS 88247-84-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.