Active ingredientTioproninCat. No. P-T128-001CAS 1953-02-2
Drag to rotate
Impurity or related compound · Tiopronin family
Pharmaceutical analytical standardTiopronin-Cysteine Disulfide
Synonyms: Thiola-cysteine disulfide, Mercaptopropionylglycine-cysteine disulfide, L-Alanine, 3-((2-((carboxymethyl)amino)-1-methyl-2-oxoethyl)dithio)-, S-((1-((carboxymethyl)amino)-1-oxopropan-2-yl)thio)-L-cysteine
- Cat. No.
- P-T128-012
- CAS
- 77591-18-5
- Alternative CAS
- N/A
- Formula
- C8H14N2O5S2
- Molecular weight
- 282.33 g/mol
- Category
- Impurity or related compound
Family: Tiopronin
A thiol-containing drug used to prevent cystine kidney stones in severe cystinuria, an inherited disease in which urine contains too much cystine; approved in the United States in 1988.
Did you know?It works by a chemical swap: it reacts with cystine to form a water-soluble mixed disulphide, so the free cystine in urine falls below the level at which it crystallises.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Tiopronin family
Active ingredientTioproninCat. No. P-T128-001CAS 1953-02-2
Isotopically labelledTiopronin-d3Cat. No. P-T128-002CAS 1189700-74-0
Impurity2-(2-chloropropanamido)acetic acidCat. No. P-T128-003CAS 85038-45-5
ImpurityTiopronin Dimer (Mixture of Diastereoisomers)Cat. No. P-T128-004CAS 21269-37-4
ImpurityTiopronin Impurity 1Cat. No. P-T128-006
ImpurityTiopronin Impurity 2Cat. No. P-T128-007
ImpurityTiopronin Impurity 3Cat. No. P-T128-008
ImpurityTiopronin SulfoneCat. No. P-T128-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.