Active ingredientTiotropium BromideCat. No. P-T129-001CAS 136310-93-5
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Pharmacopoeial impurity · Tiotropium family
Pharmaceutical analytical standardTiotropium EP Impurity D
- Cat. No.
- P-T129-032
- CAS
- 136310-66-2
- Alternative CAS
- N/A
- Formula
- C18H19NO3S2
- Molecular weight
- 361.47 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Tiotropium
A long-acting anticholinergic bronchodilator (LAMA), approved in 2002: it blocks the M3 muscarinic receptors of the airways, relaxing them, and is used as maintenance treatment for COPD and asthma.
Did you know?It detaches extremely slowly from airway M3 receptors (half of the bound molecules are released in about 35 hours), while leaving other muscarinic receptors faster: this is why its effect lasts a whole day.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Tiotropium family
Active ingredientTiotropium BromideCat. No. P-T129-001CAS 136310-93-5
Active ingredientTiotropium Bromide MonohydrateCat. No. P-T129-002CAS 139404-48-1
Pharmacopoeial impurityTiotropium Bromide EP Impurity ACat. No. P-T129-003CAS 4746-63-8
Pharmacopoeial impurityTiotropium Bromide EP Impurity C BromideCat. No. P-T129-004CAS 136310-95-7
ImpurityTiotropium Bromide EP Impurity D (Exo-Isomer)Cat. No. P-T129-005CAS 736108-96-6
Pharmacopoeial impurityTiotropium Bromide EP Impurity G BromideCat. No. P-T129-006CAS 1508-46-9
Pharmacopoeial impurityTiotropium Bromide EP Impurity H BromideCat. No. P-T129-007CAS 1044148-31-3
Pharmacopoeial impurityTiotropium Bromide EP Impurity J IodideCat. No. P-T129-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.