Active ingredientTolbutamideCat. No. P-T149-001CAS 64-77-7
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Stable isotope labelled · Tolbutamide family
Pharmaceutical analytical standardTolbutamide-d9
Synonyms: 1-(4-methylphenyl)sulfonyl-3-(1,1,2,2,3,3,4,4,4-nonadeuteriobutyl)urea, Tolbutamide-d9 (butyl-d9), Tolbutamide Impurity 5, N-((butyl-d9)carbamoyl)-4-methylbenzenesulfonamide
- Cat. No.
- P-T149-005
- CAS
- 1219794-57-6
- Alternative CAS
- 64-77-7 (unlabelled form)
- 473-41-6 (unlabelled form, sodium salt)
- Formula
- C12H9D9N2O3S
- Molecular weight
- 279.40 g/mol
- Category
- Stable isotope labelled
Family: Tolbutamide
A first-generation sulfonylurea, tested in people with diabetes in Berlin from 1954 and in use since the mid-1950s: it lowers blood sugar in type 2 diabetes by stimulating the pancreas to release insulin.
Did you know?Sulfonylureas grew out of research on antibacterial sulfa drugs: the first studies, carried out in Montpellier in the early 1940s, were disrupted by the German occupation during the Second World War.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Tolbutamide family
Active ingredientTolbutamideCat. No. P-T149-001CAS 64-77-7
Active ingredientTolbutamide SodiumCat. No. P-T149-002CAS 473-41-6
Isotopically labelled4-Carboxy Tolbutamide-d9Cat. No. P-T149-003CAS 1184973-50-9
Isotopically labelledHydroxy tolbutamide-d9Cat. No. P-T149-004CAS 1185112-19-9
Impurity4-Carboxy TolbutamideCat. No. P-T149-006CAS 2224-10-4
ImpurityHydroxy tolbutamideCat. No. P-T149-007CAS 5719-85-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.