Pharmacopoeial impurityTretinoin EP Impurity BCat. No. P-T187-006CAS 5352-74-9
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Active ingredient · Tretinoin family
Pharmaceutical analytical standardTretinoin
Synonyms: Retinoic Acid, All-trans-Retinoic acid, Vitamin A acid, trans-Retinoic acid, ATRA, Aberel, Eudyna, Dermairol, Renova, All-trans-Vitamin A acid, Cordes vas, Retin A, Tretin M, Retionic acid, All-trans-Vitamin A1 acid, beta-Ra, Retin-A Micro, Vitamin A1 acid, all-trans-, beta-Retinoic acid, Atralin, All-(E)-Retinoic acid, Vitamin A acid, all-trans-, NSC 122758, Retinoic acid, all-trans-, Betarretin, Kerlocal, Refissa, Oristar rna, All-trans-beta-Retinoic acid, Retisol-A, Stieva-A, Acid A Vit (Belgium, Netherlands), Altreno, Acid, all-trans-Retinoic, Aberela (Norway), Avitoin (Norway), Acnavit (Denmark), Effederm (France), Cordes VAS (Germany), A-Vitaminsyre (Denmark), Acid, Retinoic, Acid, Vitamin A, Acid, trans-Retinoic, Beta all trans Retinoic Acid, Acid, beta-all-trans-Retinoic, Tretin-X, Dermawerx zmt pak, Vesanoid, Airol, Aknoten, Epi-aberel, Aknefug, Tretinon, Retinoate, Retacnyl, Vesnaroid, Retinoic acid (GMP), Retinova, Acnavit, A-Vitaminsyre, All-trans-b-Retinoic acid, trans-Retinoate, beta-Retinoate, Nexret, Vitamin a acid, trans-, Avita, Tretinion, Vitamine A acid, All-(E)-Retinoate, All-trans-retinoic acid (ATRA), Pharmakon1600-01502016, NSC 759631
- Cat. No.
- P-T187-001
- CAS
- 302-79-4
- Alternative CAS
- 97950-17-9 (alternative CAS, same compound)
- Formula
- C20H28O2
- Molecular weight
- 300.44 g/mol
- Category
- Active ingredient (API)
It is all-trans retinoic acid, the acid form of vitamin A that guides cell growth and maturation: it is applied to the skin for acne and, taken by mouth, treats acute promyelocytic leukaemia.
Did you know?In 1985 in Shanghai, Wang Zhenyi's group used it to treat a 5-year-old girl with promyelocytic leukaemia: instead of killing the diseased cells, it pushes them to mature into normal white blood cells.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- TretinoinBP 1205
- Tretinoin CRSEP T1850000
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Metabolite9-cis-Retinoic Acid GlucuronideCat. No. P-T187-010
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Isotopically labelled4-Oxo Tretinoin-d6Cat. No. P-T187-013Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.