Active ingredientTrifluridineCat. No. P-T205-001CAS 70-00-8
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Impurity or related compound · Trifluridine family
Pharmaceutical analytical standardTrifluridine Impurity 4
Synonyms: [(2R,3S)-5-Chloro-3-hydroxyoxolan-2-yl]methyl 4-chlorobenzoate
- Cat. No.
- P-T205-009
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C12H12Cl2O4
- Molecular weight
- 291.12 g/mol
- Category
- Impurity or related compound
Family: Trifluridine
A fluorinated analogue of thymidine, one of the building blocks of DNA: approved in 1980 as eye drops against herpes keratitis, today it is also taken by mouth, together with tipiracil, for metastatic colorectal and gastric cancer.
Did you know?It looks so much like thymidine that viruses and cancer cells build it into their own DNA, but its group of three fluorine atoms prevents correct base pairing and blocks replication.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Trifluridine family
Active ingredientTrifluridineCat. No. P-T205-001CAS 70-00-8
Isotopically labelledTrifluridine Impurity 7-13C-15N2Cat. No. P-T205-002
Isotopically labelledTrifluridine-13C-15N2Cat. No. P-T205-003CAS 2086328-10-9
Impurity5,6-Dihydro-5-(trifluoromethyl)uracilCat. No. P-T205-005CAS 2145-56-4
ImpurityTrifluridine Impurity 1Cat. No. P-T205-006
ImpurityTrifluridine Impurity 2Cat. No. P-T205-007
ImpurityTrifluridine Impurity 3Cat. No. P-T205-008CAS 7057-42-3
ImpurityTrifluridine Impurity 5Cat. No. P-T205-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.