Active ingredientTropisetron HClCat. No. P-T229-001CAS 105826-92-4
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Pharmacopoeial impurity · Tropisetron family
Pharmaceutical analytical standardTropisetron EP Impurity B
Synonyms: Indole-3-Carboxylic Acid, 1H-indole-3-carboxylic acid, beta-Indolylcarboxylic acid, Indole-beta-carboxylic acid
- Cat. No.
- P-T229-003
- CAS
- 771-50-6
- Alternative CAS
- N/A
- Formula
- C9H7NO2
- Molecular weight
- 161.16 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Tropisetron
A serotonin 5-HT3 receptor antagonist, patented in 1982 and approved for medical use in 1992: it is used mainly to prevent nausea and vomiting caused by chemotherapy.
Did you know?Besides blocking 5-HT3 receptors it partially activates the alpha-7 nicotinic receptor, which is why it has also been studied for its effects on memory in animals.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Tropisetron impurity B CRSEP Y0000618
More products in the Tropisetron family
Active ingredientTropisetron HClCat. No. P-T229-001CAS 105826-92-4
Pharmacopoeial impurityTropisetron EP Impurity ACat. No. P-T229-002CAS 120-29-6
Isotopically labelledTropisetron-d3Cat. No. P-T229-005CAS 1220286-01-0
Isotopically labelledTropisetron-d5Cat. No. P-T229-006CAS 1220284-86-5
Impuritybeta-Tropisetron HClCat. No. P-T229-007
ImpurityEthyl Indole-3-carboxylateCat. No. P-T229-008CAS 776-41-0
ImpurityN-hydroxy TropisetronCat. No. P-T229-009
ImpurityTropisetron Impurity 1Cat. No. P-T229-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.