Active ingredient · Tyrothricin family
Pharmaceutical analytical standardTyrothricin
Synonyms: Dermotricine, Hydrotricine, Bactratycin, Coltirot, Martricin, Tirotricina, Solutricine, Tyroderm, Tyrosur, Dubos crude crystals, NSC 757363, Pharothricetten, Biothricin, Ginotricina, Rinotricina, Triciderm, Tyrozets, Tyrex, Caswell No. 900A, EPA Pesticide Chemical Code 006311, An antibacterial substance produced by the growth of Bacillus brevis Dubos (Fam. Bacteriaceae), Gramicidin A & Tyrocidine A
- Cat. No.
- P-T239-001
- CAS
- 1404-88-2
- Alternative CAS
- N/A
- Formula
- C65H85N11O13
- Molecular weight
- 1228.46 g/mol
- Category
- Active ingredient (API)
A mixture of two peptide antibiotics, gramicidin and tyrocidine, isolated in 1939 by microbiologist René Dubos from a soil bacterium, Bacillus brevis (now Brevibacillus brevis): too toxic for internal use, it is applied topically.
Did you know?Tyrocidine, one of its two components, is considered the first commercially available antibiotic, and Dubos's discovery helped revive interest in penicillin.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
Shipped under controlled temperature when the molecule requires it.
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Sent with every order.
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Tyrothricin CRSEP T3000000
Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.