Active ingredientVenetoclaxCat. No. P-V027-001CAS 1257044-40-8
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Nitrosamine · Venetoclax family
Pharmaceutical analytical standardVenetoclax Dinitroso Impurity
- Cat. No.
- P-V027-010
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C45H48ClN9O9S
- Molecular weight
- 926.44 g/mol
- Category
- Nitrosamine
Family: Venetoclax
A BH3-mimetic cancer medicine that blocks BCL-2, a protein that keeps leukaemia cells alive, pushing them towards programmed cell death: approved in 2016 in the United States and Europe, it is used for chronic lymphocytic leukaemia and acute myeloid leukaemia.
Did you know?It was the first approved medicine that works by blocking an interaction between proteins: it mimics the BH3 proteins, which normally bind to BCL-2 to start the cell's self-destruction.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Venetoclax family
Active ingredientVenetoclaxCat. No. P-V027-001CAS 1257044-40-8
MetaboliteVenetoclax-M27Cat. No. P-V027-002CAS 2097938-69-5
Isotopically labelledVenetoclax-d8Cat. No. P-V027-003CAS 1257051-06-1
NitrosamineN-Nitroso (Indole)-VenetoclaxCat. No. P-V027-004
NitrosamineN-Nitroso Deschloro VenetoclaxCat. No. P-V027-005
NitrosamineN-Nitroso VenetoclaxCat. No. P-V027-006
NitrosamineN-Nitroso Venetoclax Impurity 1Cat. No. P-V027-008
NitrosamineN-Nitroso Venetoclax Impurity 2Cat. No. P-V027-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.