Active ingredientOsimertinibCat. No. P-O041-001CAS 1421373-65-0
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Impurity or related compound · Osimertinib family
Pharmaceutical analytical standardVistusertib
Synonyms: Benzamide, 3-(2,4-bis((3S)-3-methyl-4-morpholinyl)pyrido(2,3-d)pyrimidin-7-yl)-N-methyl-, Vistusertib (JAN/INN), NSC 767189, NSC 780879, NSC 787289, NSC 799345
- Cat. No.
- P-O041-059
- CAS
- 1009298-59-2
- Alternative CAS
- N/A
- Formula
- C25H30N6O3
- Molecular weight
- 462.55 g/mol
- Category
- Impurity or related compound
Family: Osimertinib
A third-generation EGFR tyrosine kinase inhibitor for non-small cell lung cancer with EGFR mutations, including the T790M resistance mutation; approved in the United States in November 2015.
Did you know?Designed from 2009 onwards, it binds irreversibly to cysteine 797 of the receptor and was approved a record 2 years and 9 months after the first dose in humans.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Osimertinib family
Active ingredientOsimertinibCat. No. P-O041-001CAS 1421373-65-0
Active ingredientOsimertinib MesylateCat. No. P-O041-002CAS 1421373-66-1
Isotopically labelledAdonertinibCat. No. P-O041-003CAS 2211116-92-4
Isotopically labelledOsimertinib Impurity 5-13C-d3Cat. No. P-O041-004
Isotopically labelledOsimertinib Impurity 5-d3Cat. No. P-O041-005CAS 2211116-74-2
Isotopically labelledOsimertinib Impurity 6-13C-d3Cat. No. P-O041-006
Isotopically labelledOsimertinib Impurity 7 Chloride-d6Cat. No. P-O041-007
Isotopically labelledOsimertinib Impurity 8-d6Cat. No. P-O041-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.