Active ingredientZoledronic AcidCat. No. P-Z022-001CAS 118072-93-8
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Pharmacopoeial impurity · Zoledronic Acid family
Pharmaceutical analytical standardZoledronic Acid EP Impurity F
Synonyms: Phosphoric Acid, Orthophosphoric acid, o-Phosphoric acid, Wc-reiniger, Sonac, Evits, Phosphorsaeureloesungen, FEMA No. 2900, Fosforzuuroplossingen, Vococid, White phosphoric acid, Amberphos 54, NSC 80804, INS NO.338, Phosphoric acid (aqueous), Naturasil Acne, Pre-Sept Activator, Naturasil Bite Relief, Naturasil Cherry Angiomas, Bestmade Natural Products Phos Acid, Caswell No. 662, Phosphoric acid, ortho-, Trihydroxidooxidophosphorus, EPA Pesticide Chemical Code 076001, Ortophosphate, Phosphoric cid, NFB Orthophosphate, Orthophosphate(3-), Tetraoxophosphoric acid, Orthophosphate (PO43-), Trihydrogen tetraoxophosphate(3-)
- Cat. No.
- P-Z022-006
- CAS
- 7664-38-2
- Alternative CAS
- 7757-93-9 (calcium salt)
- 7758-11-4 (potassium salt)
- 7778-77-0 (potassium salt)
- 7789-77-7 (calcium salt hydrate)
- 10028-24-7 (sodium salt hydrate)
- 62046-92-8 (alternative CAS, same compound)
- Formula
- H3PO4
- Molecular weight
- 97.99 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Zoledronic Acid
A bisphosphonate carrying an imidazole ring, patented in 1986 and approved in the United States in 2001: it strengthens bone by restraining osteoclasts and is used for osteoporosis, Paget's disease, bone metastases and hypercalcaemia of cancer.
Did you know?It is among the most potent bisphosphonates: in relative potency tables, where the older etidronate scores 1, zoledronic acid reaches 10,000.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Zoledronic Acid family
Active ingredientZoledronic AcidCat. No. P-Z022-001CAS 118072-93-8
Active ingredientZoledronic Acid MonohydrateCat. No. P-Z022-002CAS 165800-06-6
Pharmacopoeial impurityZoledronic acid EP Impurity ACat. No. P-Z022-003CAS 1627731-60-5
Pharmacopoeial impurityZoledronic Acid EP Impurity DCat. No. P-Z022-004CAS 22884-10-2
Pharmacopoeial impurityZoledronic Acid EP Impurity ECat. No. P-Z022-005CAS 13598-36-2
Isotopically labelledZoledronic Acid EP Impurity D-13C2-15N2Cat. No. P-Z022-007CAS 1184983-00-3
Isotopically labelledZoledronic-d3 AcidCat. No. P-Z022-008CAS 1134798-26-7
ImpurityZoledronic Acid Impurity 1Cat. No. P-Z022-009CAS 1334703-07-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.