Family · Pharmaceutical analytical standards
Cladribine
A synthetic analogue of deoxyadenosine, studied as a medicine in the 1980s by Ernest Beutler and Dennis Carson at the Scripps Research Institute in California. Approved in the United States in the early 1990s for hairy cell leukaemia, since 2017 it has also been used in Europe for relapsing multiple sclerosis. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards and other impurities.
Did you know?The secret is a single chlorine atom at position 2: it makes the molecule more resistant to adenosine deaminase, the enzyme that would quickly break down natural deoxyadenosine, so the drug can act on lymphocytes for a long time.
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EDQM standards 3
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
