Active ingredientCladribineCat. No. P-C180-001CAS 4291-63-8
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Impurity or related compound · Cladribine family
Pharmaceutical analytical standardCladribine Mono Benzoate Impurity
Synonyms: Cladribine Impurity 1
- Cat. No.
- P-C180-012
- CAS
- 152463-98-4
- Alternative CAS
- N/A
- Formula
- C18H18ClN5O4
- Molecular weight
- 403.82 g/mol
- Category
- Impurity or related compound
Family: Cladribine
A synthetic analogue of deoxyadenosine, studied as a medicine in the 1980s by Ernest Beutler and Dennis Carson at the Scripps Research Institute in California. Approved in the United States in the early 1990s for hairy cell leukaemia, since 2017 it has also been used in Europe for relapsing multiple sclerosis.
Did you know?The secret is a single chlorine atom at position 2: it makes the molecule more resistant to adenosine deaminase, the enzyme that would quickly break down natural deoxyadenosine, so the drug can act on lymphocytes for a long time.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Cladribine family
Active ingredientCladribineCat. No. P-C180-001CAS 4291-63-8
Active ingredientCladribine PhosphateCat. No. P-C180-002
Pharmacopoeial impurityCladribine EP Impurity ACat. No. P-C180-003CAS 4546-70-7
Pharmacopoeial impurityCladribine EP Impurity BCat. No. P-C180-004CAS 24757-70-8
Pharmacopoeial impurityCladribine EP Impurity CCat. No. P-C180-005CAS 1839-18-5
Pharmacopoeial impurityCladribine EP Impurity DCat. No. P-C180-006CAS 5542-92-7
Pharmacopoeial impurityCladribine EP Impurity FCat. No. P-C180-007CAS 619-55-6
Pharmacopoeial impurityCladribine EP Impurity GCat. No. P-C180-008CAS 99-75-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.