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Family · Pharmaceutical analytical standards

Colistin

A polypeptide antibiotic of the polymyxin family (polymyxin E), isolated in Japan in 1949 and in clinical use since 1959 against gram-negative bacteria; since the 1990s it has returned to the spotlight as a reserve weapon against multidrug-resistant bacteria. This family brings together the active ingredient and other impurities.

Did you know?Y. Koyama in Japan discovered it in a flask in which the bacterium Bacillus polymyxa var. colistinus was fermenting: it works by stripping calcium and magnesium ions from the outer membrane of bacteria, which then falls apart.

Colistin Sulfate (Mixture of A and B compound)Go to the active ingredient →

EDQM standards 1

The official European Pharmacopoeia standards for this family.

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