ImpurityColistin A PentatrifluoroacetateCat. No. P-C245-004CAS 7722-44-3
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Active ingredient · Colistin family
Pharmaceutical analytical standardColistin Sulfate (Mixture of A and B compound)
Synonyms: Colistin Sulfate, Belcomycine, Cantrex, Colimycin sulphate, Belcomycin, Colimycin sulfate, Coly-Mycin S, Kannasyn, Kantrim, NSC 759273
- Cat. No.
- P-C245-001
- CAS
- 1264-72-8
- Alternative CAS
- N/A
- Formula
- C105H206N32O32S2
- Molecular weight
- 2493.11 g/mol
- Category
- Active ingredient (API)
A polypeptide antibiotic of the polymyxin family (polymyxin E), isolated in Japan in 1949 and in clinical use since 1959 against gram-negative bacteria; since the 1990s it has returned to the spotlight as a reserve weapon against multidrug-resistant bacteria.
Did you know?Y. Koyama in Japan discovered it in a flask in which the bacterium Bacillus polymyxa var. colistinus was fermenting: it works by stripping calcium and magnesium ions from the outer membrane of bacteria, which then falls apart.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
More products in the Colistin family
ImpurityColistin A PentatrifluoroacetateCat. No. P-C245-004CAS 7722-44-3
ImpurityColistin B PentatrifluoroacetateCat. No. P-C245-005CAS 7239-48-7
ImpurityColistin Impurity 1Cat. No. P-C245-007
ImpurityColistin Impurity 2Cat. No. P-C245-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.