Family · Pharmaceutical analytical standards
Geldanamycin
An antitumour antibiotic of the benzoquinone ansamycin family, produced by the bacterium Streptomyces hygroscopicus: it was the first discovered inhibitor of Hsp90, a chaperone protein that helps other proteins keep their correct shape. This family brings together the active ingredient and other impurities.
Did you know?Too toxic to the liver to become a medicine itself, it founded a lineage: its semi-synthetic derivative 17-AAG was the first Hsp90 inhibitor evaluated in clinical trials.
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