Active ingredientGeldanamycinCat. No. P-G022-001CAS 30562-34-6
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Impurity or related compound · Geldanamycin family
Pharmaceutical analytical standard17-Allylamino-17-Demethoxygeldanamycin
Synonyms: Tanespimycin, NSC 330507, Tanespimycine, Tanespimicina, Tanespimycinum, Geldanamycin, 17-demethoxy-17-(2-propenylamino)-, Geldanamycin, 17-allylamino-17-demethoxy-, Tanespimycin (17-AAG), Tanespimycina, Allylamino-17-demethoxygeldanamycin, 17-, NSC 704057, Geldanamycin, des-O-methyl-17-allylamino-
- Cat. No.
- P-G022-002
- CAS
- 75747-14-7
- Alternative CAS
- 911710-03-7 (hydrochloride)
- Formula
- C31H43N3O8
- Molecular weight
- 585.70 g/mol
- Category
- Impurity or related compound
Family: Geldanamycin
An antitumour antibiotic of the benzoquinone ansamycin family, produced by the bacterium Streptomyces hygroscopicus: it was the first discovered inhibitor of Hsp90, a chaperone protein that helps other proteins keep their correct shape.
Did you know?Too toxic to the liver to become a medicine itself, it founded a lineage: its semi-synthetic derivative 17-AAG was the first Hsp90 inhibitor evaluated in clinical trials.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Geldanamycin family
Active ingredientGeldanamycinCat. No. P-G022-001CAS 30562-34-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.