Family · Pharmaceutical analytical standards
Leflunomide
A disease-modifying antirheumatic drug: it blocks dihydroorotate dehydrogenase, an enzyme that activated lymphocytes need in order to multiply. It was approved in 1998 for rheumatoid arthritis. This family brings together the active ingredient, pharmacopoeial impurities, metabolites, labelled standards, nitrosamines and other impurities.
Did you know?In the body it turns into teriflunomide simply by opening one ring of the molecule: this is the real active substance, which was itself approved in 2012 in the United States for multiple sclerosis.
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EDQM standards 3
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
