Active ingredientLeflunomideCat. No. P-L030-001CAS 75706-12-6
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Stable isotope labelled · Leflunomide family
Pharmaceutical analytical standardLeflunomide-d4
- Cat. No.
- P-L030-012
- CAS
- 1189987-23-2
- Alternative CAS
- 75706-12-6 (unlabelled form)
- Formula
- C12H5D4F3N2O2
- Molecular weight
- 274.23 g/mol
- Category
- Stable isotope labelled
Family: Leflunomide
A disease-modifying antirheumatic drug: it blocks dihydroorotate dehydrogenase, an enzyme that activated lymphocytes need in order to multiply. It was approved in 1998 for rheumatoid arthritis.
Did you know?In the body it turns into teriflunomide simply by opening one ring of the molecule: this is the real active substance, which was itself approved in 2012 in the United States for multiple sclerosis.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Leflunomide family
Active ingredientLeflunomideCat. No. P-L030-001CAS 75706-12-6
Pharmacopoeial impurityLeflunomide EP Impurity A HydrochlorideCat. No. P-L030-002CAS 90774-69-9
Pharmacopoeial impurityLeflunomide EP Impurity BCat. No. P-L030-003CAS 163451-81-8
Pharmacopoeial impurityLeflunomide EP Impurity CCat. No. P-L030-004CAS 61643-23-0
Pharmacopoeial impurityLeflunomide EP Impurity DCat. No. P-L030-005CAS 42831-50-5
Pharmacopoeial impurityLeflunomide EP Impurity ECat. No. P-L030-006CAS 208401-20-1
Pharmacopoeial impurityLeflunomide EP Impurity FCat. No. P-L030-007CAS 1403564-06-6
Pharmacopoeial impurityLeflunomide EP Impurity GCat. No. P-L030-008CAS 724429-16-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.