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Family · Pharmaceutical analytical standards

Linaclotide

A synthetic 14-amino-acid peptide that activates the guanylate cyclase C receptor in the gut, staying in the gastrointestinal tract with almost none reaching the blood. It was approved in 2012 in the US and Europe for irritable bowel syndrome with constipation. This family brings together the active ingredient, labelled standards and other impurities.

Did you know?It is a hybrid inspired by a bacterial toxin: its design combines the heat-stable enterotoxin of Escherichia coli with the human gut hormones guanylin and uroguanylin, and it is held in shape by three disulfide bridges.

LinaclotideGo to the active ingredient →
LinaclotideActive ingredientLinaclotideCat. No. P-L065-001CAS 851199-59-2

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