Active ingredientLinaclotideCat. No. P-L065-001CAS 851199-59-2
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Impurity or related compound · Linaclotide family
Pharmaceutical analytical standardAcylated Linaclotide
Synonyms: Linaclotide Impurity 3(Acylated Linaclotide)
- Cat. No.
- P-L065-004
- CAS
- 1422389-17-0
- Alternative CAS
- N/A
- Formula
- C61H81N15O22S6
- Molecular weight
- 1568.76 g/mol
- Category
- Impurity or related compound
Family: Linaclotide
A synthetic 14-amino-acid peptide that activates the guanylate cyclase C receptor in the gut, staying in the gastrointestinal tract with almost none reaching the blood. It was approved in 2012 in the US and Europe for irritable bowel syndrome with constipation.
Did you know?It is a hybrid inspired by a bacterial toxin: its design combines the heat-stable enterotoxin of Escherichia coli with the human gut hormones guanylin and uroguanylin, and it is held in shape by three disulfide bridges.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Linaclotide family
Active ingredientLinaclotideCat. No. P-L065-001CAS 851199-59-2
Active ingredientLinaclotide AcetateCat. No. P-L065-002CAS 851199-60-5
Isotopically labelledLinaclotide-d4Cat. No. P-L065-003
ImpurityAspartyl LinaclotideCat. No. P-L065-005CAS 1207977-38-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.