Family · Pharmaceutical analytical standards
Nilotinib
A second-generation BCR-ABL tyrosine kinase inhibitor, approved in 2007 for Philadelphia chromosome-positive chronic myeloid leukaemia, first in imatinib-resistant cases and later also at diagnosis. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards, nitrosamines and other impurities.
Did you know?It was designed starting from the crystal structure of imatinib bound to its target: the targeted changes make it 10 to 30 times more potent at blocking BCR-ABL.
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EDQM standards 4
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
