Active ingredientNilotinibCat. No. P-N063-001CAS 641571-10-0
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Impurity or related compound · Nilotinib family
Pharmaceutical analytical standardNilotinib Impurity 25
Synonyms: Nilotinib N-Oxide, Benzamide, 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(1-oxido-3-pyridinyl)-2-pyrimidinyl)amino)-
- Cat. No.
- P-N063-046
- CAS
- 1246817-85-5
- Alternative CAS
- N/A
- Formula
- C28H22F3N7O2
- Molecular weight
- 545.52 g/mol
- Category
- Impurity or related compound
Family: Nilotinib
A second-generation BCR-ABL tyrosine kinase inhibitor, approved in 2007 for Philadelphia chromosome-positive chronic myeloid leukaemia, first in imatinib-resistant cases and later also at diagnosis.
Did you know?It was designed starting from the crystal structure of imatinib bound to its target: the targeted changes make it 10 to 30 times more potent at blocking BCR-ABL.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Nilotinib family
Active ingredientNilotinibCat. No. P-N063-001CAS 641571-10-0
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Pharmacopoeial impurityNilotinib EP Impurity ACat. No. P-N063-003CAS 641571-11-1
Pharmacopoeial impurityNilotinib EP Impurity BCat. No. P-N063-004CAS 18595-18-1
Pharmacopoeial impurityNilotinib EP Impurity CCat. No. P-N063-005CAS 2458-12-0
Pharmacopoeial impurityNilotinib EP Impurity DCat. No. P-N063-006CAS 641569-94-0
Pharmacopoeial impurityNilotinib EP Impurity ECat. No. P-N063-007CAS 2119583-26-3
Pharmacopoeial impurityNilotinib EP Impurity FCat. No. P-N063-008CAS 2119583-24-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.