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Family · Pharmaceutical analytical standards

Phenylbutyrate

An aromatic fatty acid, used as its sodium salt and approved in the United States in 1996 for urea cycle disorders: in the body it becomes phenylacetate, which binds the nitrogen of glutamine and has it excreted in the urine instead of urea. This family brings together pharmacopoeial impurities, labelled standards and other impurities.

Did you know?The alternative nitrogen disposal pathway was discovered in the early 1980s at Johns Hopkins by Saul Brusilow and Mark Batshaw: phenylbutyrate replaced phenylacetate because, unlike it, it lacks an unpleasant smell.

EDQM standards 2

The official European Pharmacopoeia standards for this family.

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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.