Pharmacopoeial impurityPhenylbutyrate EP Impurity ACat. No. P-P092-002CAS 2051-95-8
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Impurity or related compound · Phenylbutyrate family
Pharmaceutical analytical standardSodium Phenylbutyrate
Synonyms: Relyvrio (sodium phenylbutyrate/taurursodiol), sodium 4-phenylbutanoate, Buphenyl, TriButyrate, Benzenebutanoic acid, sodium salt, Ammonaps, Pheburane, Olpruva, NSC 657802, Relyvrio component sodium phenylbutyrate, Ambutyrate, Krisospb-8696, Phenylbutyrate sodium, Phenylbutyrate, Ammonapse, Lunaphen, NaPb, Phenylbutyrate Na, Phenylbutyric acid sodium salt, Sodium phenylbutyrate (JAN/USP), ALBRIOZA component SODIUM PHENYLBUTYRATE, Sodium phenylbutyrate component of relyvrio
- Cat. No.
- P-P092-006
- CAS
- 1716-12-7
- Alternative CAS
- 1821-12-1 (free acid)
- 1262970-43-3 (free acid)
- 22889-95-8 (potassium salt)
- Formula
- C10H11NaO2
- Molecular weight
- 186.19 g/mol
- Category
- Impurity or related compound
Family: Phenylbutyrate
An aromatic fatty acid, used as its sodium salt and approved in the United States in 1996 for urea cycle disorders: in the body it becomes phenylacetate, which binds the nitrogen of glutamine and has it excreted in the urine instead of urea.
Did you know?The alternative nitrogen disposal pathway was discovered in the early 1980s at Johns Hopkins by Saul Brusilow and Mark Batshaw: phenylbutyrate replaced phenylacetate because, unlike it, it lacks an unpleasant smell.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Sodium phenylbutyrate CRSEP Y0000808
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Isotopically labelledPhenylbutyrate-d11 Sodium SaltCat. No. P-P092-005CAS 1392208-11-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
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