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Family · Pharmaceutical analytical standards

Sorafenib

An oral multikinase inhibitor that slows both tumour growth and the blood vessels that feed it: approved in the US in 2005 for advanced kidney cancer and in 2007 for hepatocellular carcinoma. This family brings together the active ingredient, pharmacopoeial impurities, metabolites, labelled standards, nitrosamines and other impurities.

Did you know?It came from a search for biaryl ureas able to block the C-RAF kinase, a switch for cell growth, and turned out to hit the VEGFR receptors of blood vessels as well.

SorafenibGo to the active ingredient →
SorafenibActive ingredientSorafenibCat. No. P-S066-001CAS 284461-73-0
Sorafenib-d3Isotopically labelledSorafenib-d3Cat. No. P-S066-014CAS 1130115-44-4
Sorafenib-d4Isotopically labelledSorafenib-d4Cat. No. P-S066-015CAS 1207560-07-3
FlucofuronImpurityFlucofuronCat. No. P-S066-034CAS 370-50-3

EDQM standards 4

The official European Pharmacopoeia standards for this family.

Reference substanceSorafenib CRSEDQM code Y0002098Family Sorafenib

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