Active ingredientSorafenibCat. No. P-S066-001CAS 284461-73-0
Drag to rotate
Impurity or related compound · Sorafenib family
Pharmaceutical analytical standardSorafenib Urea Dimer Methyl Ester
- Cat. No.
- P-S066-050
- CAS
- 2204442-52-2
- Alternative CAS
- N/A
- Formula
- C27H23N5O6
- Molecular weight
- 513.51 g/mol
- Category
- Impurity or related compound
Family: Sorafenib
An oral multikinase inhibitor that slows both tumour growth and the blood vessels that feed it: approved in the US in 2005 for advanced kidney cancer and in 2007 for hepatocellular carcinoma.
Did you know?It came from a search for biaryl ureas able to block the C-RAF kinase, a switch for cell growth, and turned out to hit the VEGFR receptors of blood vessels as well.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Sorafenib family
Active ingredientSorafenibCat. No. P-S066-001CAS 284461-73-0
Active ingredientSorafenib TosylateCat. No. P-S066-002CAS 475207-59-1
Pharmacopoeial impuritySorafenib EP Impurity ACat. No. P-S066-004CAS 284462-37-9
Pharmacopoeial impuritySorafenib EP Impurity CCat. No. P-S066-005CAS 320-51-4
Pharmacopoeial impuritySorafenib EP Impurity DCat. No. P-S066-006CAS 2206827-14-5
Pharmacopoeial impuritySorafenib EP Impurity ECat. No. P-S066-007CAS 284670-98-0
Pharmacopoeial impuritySorafenib EP Impurity FCat. No. P-S066-008CAS 1285533-84-7
Pharmacopoeial impuritySorafenib EP Impurity GCat. No. P-S066-009CAS 18585-06-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.