Family · Pharmaceutical analytical standards

Tofacitinib

A Janus kinase (JAK) inhibitor in tablets, the first approved for rheumatoid arthritis (United States, 2012) and later for other inflammatory diseases. It switches off, from inside the cells, the signals that drive inflammation. This family brings together the active ingredient, labelled standards, nitrosamines and other impurities.

Did you know?Janus kinases are named after Janus, the two-faced Roman god, because they have two almost identical halves: an active one and one that regulates it.

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Active ingredientTofacitinibCat. No. P-T142-001CAS 477600-75-2

Active ingredientTofacitinib CitrateCat. No. P-T142-002CAS 540737-29-9

Isotopically labelledN-Nitroso N2-Nitroso Tofacitinib Impurity 9-d3Cat. No. P-T142-003

Isotopically labelledTofacitinib Impurity 21-d3Cat. No. P-T142-004

Isotopically labelledTofacitinib-d3 CitrateCat. No. P-T142-005CAS 2701680-77-3

NitrosamineN-Nitroso TofacitinibCat. No. P-T142-006

NitrosamineN-Nitroso Tofacitinib Impurity 1Cat. No. P-T142-007

NitrosamineN-Nitroso Tofacitinib Impurity 2Cat. No. P-T142-008

NitrosamineN-Nitroso Tofacitinib Impurity 3Cat. No. P-T142-009

NitrosamineN-Nitroso Tofacitinib Impurity 4Cat. No. P-T142-010

NitrosamineN-Nitroso Tofacitinib Impurity 5Cat. No. P-T142-011

NitrosamineN-Nitroso Tofacitinib Impurity 6Cat. No. P-T142-012

NitrosamineN-Nitroso N1-Nitroso Tofacitinib Impurity 7Cat. No. P-T142-013

NitrosamineN-Nitroso N1-Nitroso Tofacitinib Impurity 8Cat. No. P-T142-014

NitrosamineN-Nitroso N2-Nitroso Tofacitinib Impurity 9Cat. No. P-T142-015

NitrosamineN-Nitroso N2-Nitroso Tofacitinib Impurity 10Cat. No. P-T142-016

ImpurityTofacitinib Impurity 1Cat. No. P-T142-017CAS 1354469-76-3

Impurity(3S,4R)-TofacitinibCat. No. P-T142-019CAS 1092578-48-7

ImpurityTofacitinib Impurity 2 BromideCat. No. P-T142-020CAS 1615709-89-1

Impurity1-Benzyl-N,4-dimethylpiperidin-3-amineCat. No. P-T142-021CAS 384338-23-2

ImpurityTofacitinib Impurity 3Cat. No. P-T142-022CAS 1374010-02-2

Impurity2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidineCat. No. P-T142-023CAS 90213-66-4

ImpurityTofacitinib Impurity 4Cat. No. P-T142-024CAS 934524-10-4

Impurity2,6-Dichloropyrimidin-4-amineCat. No. P-T142-025CAS 10132-07-7

ImpurityTofacitinib Impurity 5Cat. No. P-T142-026CAS 2812-23-9

Impurity2-Chloro-2',5'-acetoxylidideCat. No. P-T142-027CAS 5177-35-5

ImpurityTofacitinib Impurity 6Cat. No. P-T142-028CAS 2282653-53-4

Impurity2-Chloro-N-(2,3-dimethylphenyl)acetamideCat. No. P-T142-029CAS 2564-07-0

Impurity2-Chloro-N-(2,4-dimethylphenyl)acetamideCat. No. P-T142-030CAS 39106-10-0

Impurity2-Descyano-2-ethyl Formyl-tofacitinibCat. No. P-T142-031CAS 1675248-18-6

ImpurityTofacitinib Impurity 7Cat. No. P-T142-032CAS 3680-71-5

ImpurityTofacitinib Impurity 8 ChlorideCat. No. P-T142-033CAS 1638499-35-0

ImpurityTofacitinib Impurity 9Cat. No. P-T142-034CAS 134965-85-8

ImpurityTofacitinib Impurity 10Cat. No. P-T142-035CAS 100047-45-8

ImpurityTofacitinib Impurity 11Cat. No. P-T142-036CAS 948015-51-8

Impurity4-Carbamoyloxane-4-carboxylic acidCat. No. P-T142-037CAS 2003093-69-2

ImpurityTofacitinib Impurity 12Cat. No. P-T142-038CAS 16372-08-0

Impurity4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidineCat. No. P-T142-039CAS 479633-63-1

Impurity4-Chloro-7H-pyrrolo[2,3-d]pyrimidineCat. No. P-T142-040CAS 3680-69-1

Impurity5,6-Dihydro Tofacitinib Citrate SaltCat. No. P-T142-041CAS 1809002-40-1

Impurity6-AminouracilCat. No. P-T142-042CAS 873-83-6

ImpurityTofacitinib Impurity 13Cat. No. P-T142-043CAS 2250241-69-9

ImpurityTofacitinib Impurity 14Cat. No. P-T142-044CAS 1229041-97-7

Impurity7H-pyrrolo[2,3-d]pyrimidine-2,4-diolCat. No. P-T142-045CAS 39929-79-8

Impurity(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amineCat. No. P-T142-046CAS 1354621-59-2

ImpurityCyanoacetyl TofacitinibCat. No. P-T142-049CAS 2459302-77-1

ImpurityDBUCat. No. P-T142-050CAS 6674-22-2

ImpurityTofacitinib Impurity 15Cat. No. P-T142-051CAS 5337-04-2

ImpurityEthyl 2,4-dicyano-3-oxobutanoateCat. No. P-T142-052CAS 861612-04-6

ImpurityN,4-Dimethylpyridin-3-amineCat. No. P-T142-053CAS 77862-24-9

ImpurityTofacitinib Impurity 16Cat. No. P-T142-054CAS 90953-01-8

ImpurityTofacitinib Impurity 17Cat. No. P-T142-055CAS 1638499-36-1

ImpurityTofacitinib Impurity 18Cat. No. P-T142-056CAS 294852-91-8

ImpurityN-Desmethyl TofacitinibCat. No. P-T142-057CAS 1527525-58-1

Impurityrac-Tofacitinib (Mixture of Diastereomers)Cat. No. P-T142-058CAS 344418-92-4

Impurityrac-trans-TofacitinibCat. No. P-T142-059CAS 2734856-31-4

ImpurityTofacitinib Impurity 20Cat. No. P-T142-062

ImpurityTofacitinib Impurity 21Cat. No. P-T142-063CAS 477600-74-1

ImpurityTofacitinib Impurity 22Cat. No. P-T142-064

ImpurityTofacitinib Impurity 23 DihydrochlorideCat. No. P-T142-065

ImpurityTofacitinib Impurity 24 DihydrochlorideCat. No. P-T142-066

ImpurityTofacitinib Impurity 25Cat. No. P-T142-067CAS 2227197-38-6

ImpurityTofacitinib Impurity 26Cat. No. P-T142-068

ImpurityTofacitinib Impurity 27 (rac-trans)Cat. No. P-T142-069CAS 2459302-75-9

ImpurityTofacitinib Impurity 28Cat. No. P-T142-070

ImpurityTofacitinib Impurity 29Cat. No. P-T142-071

ImpurityTofacitinib Impurity 30Cat. No. P-T142-072CAS 2101951-20-4

ImpurityTofacitinib Impurity 31Cat. No. P-T142-073CAS 2315287-12-6

ImpurityTofacitinib Impurity 32Cat. No. P-T142-074CAS 2459302-85-1

ImpurityTofacitinib Impurity 33 Di-p-toluoyl-L-tartrateCat. No. P-T142-075

ImpurityTofacitinib Impurity 34Cat. No. P-T142-076CAS 923036-25-3

ImpurityTofacitinib Impurity 35 Di-p-toluoyl-D-tartrateCat. No. P-T142-077

ImpurityTofacitinib Impurity 36 Di-p-toluoyl-D-tartrateCat. No. P-T142-078

ImpurityTofacitinib Impurity 37Cat. No. P-T142-079

ImpurityTofacitinib Impurity 38Cat. No. P-T142-080

ImpurityTofacitinib Impurity 39Cat. No. P-T142-081

ImpurityTofacitinib Impurity 40Cat. No. P-T142-082CAS 2102040-00-4

ImpurityTofacitinib Impurity 41Cat. No. P-T142-083

ImpurityTofacitinib Impurity 42Cat. No. P-T142-084

ImpurityTofacitinib Impurity 43Cat. No. P-T142-085

ImpurityTofacitinib Impurity 44 (Mixture of Z and E Isomers)Cat. No. P-T142-086

ImpurityTofacitinib Impurity 45Cat. No. P-T142-087CAS 2135932-01-1

ImpurityTofacitinib Impurity 46Cat. No. P-T142-088CAS 1640971-60-3

ImpurityTofacitinib Impurity 47Cat. No. P-T142-089

ImpurityTofacitinib Impurity 48Cat. No. P-T142-090

ImpurityTofacitinib Impurity 49Cat. No. P-T142-091CAS 2227199-31-5

ImpurityTofacitinib Impurity 50Cat. No. P-T142-092

ImpurityTofacitinib Impurity 51Cat. No. P-T142-093

ImpurityTofacitinib Impurity 52Cat. No. P-T142-094

ImpurityTofacitinib Impurity 53Cat. No. P-T142-095

ImpurityTofacitinib Impurity 54Cat. No. P-T142-096CAS 2504210-48-2

ImpurityTofacitinib Impurity 55Cat. No. P-T142-097

ImpurityTofacitinib Impurity 56Cat. No. P-T142-098CAS 923036-30-0

ImpurityTofacitinib Impurity 57Cat. No. P-T142-099

ImpurityTofacitinib Impurity 57 DihydrochlorideCat. No. P-T142-100

Impurity(3R,4S)-TofacitinibCat. No. P-T142-101CAS 1092578-46-5

ImpurityTofacitinib Impurity 59Cat. No. P-T142-102CAS 2374700-39-5

ImpurityTofacitinib Impurity 60Cat. No. P-T142-103CAS 2407039-29-4

ImpurityTofacitinib Impurity 61Cat. No. P-T142-104

ImpurityTofacitinib Impurity 62Cat. No. P-T142-105

ImpurityTofacitinib Impurity 63Cat. No. P-T142-106

ImpurityTofacitinib Impurity 64Cat. No. P-T142-107

ImpurityTofacitinib Impurity 64 DihydrochlorideCat. No. P-T142-108

ImpurityTofacitinib Impurity 65Cat. No. P-T142-109CAS 2280085-84-7

ImpurityTofacitinib Impurity 66Cat. No. P-T142-110CAS 1966148-50-4

ImpurityTofacitinib Impurity 67Cat. No. P-T142-111

ImpurityTofacitinib Impurity 68Cat. No. P-T142-112CAS 1616760-97-4

ImpurityTofacitinib Impurity 69Cat. No. P-T142-113

ImpurityTofacitinib Impurity 70Cat. No. P-T142-114

ImpurityTofacitinib Impurity 71Cat. No. P-T142-115

ImpurityTofacitinib Impurity 72Cat. No. P-T142-116

ImpurityTofacitinib Impurity 73Cat. No. P-T142-117

ImpurityTofacitinib Impurity 74Cat. No. P-T142-118

ImpurityTofacitinib Impurity 75Cat. No. P-T142-119

ImpurityTofacitinib Impurity 76Cat. No. P-T142-120CAS 1824188-05-7

ImpurityTofacitinib Impurity 77Cat. No. P-T142-121

ImpurityTofacitinib Impurity 78Cat. No. P-T142-122

ImpurityTofacitinib Impurity 79Cat. No. P-T142-123

ImpurityTofacitinib Impurity 80Cat. No. P-T142-124

ImpurityTofacitinib Impurity 82Cat. No. P-T142-126CAS 2378663-15-9

ImpurityTofacitinib Impurity 82 DihydrochlorideCat. No. P-T142-127

ImpurityTofacitinib Impurity 83Cat. No. P-T142-128CAS 2328165-36-0

ImpurityTofacitinib Impurity 84Cat. No. P-T142-129

ImpurityTofacitinib Impurity 85Cat. No. P-T142-130CAS 1616760-94-1

ImpurityTofacitinib Impurity 86Cat. No. P-T142-131CAS 1616760-96-3

ImpurityTofacitinib Impurity 87Cat. No. P-T142-132CAS 1616760-93-0

ImpurityTofacitinib Impurity 88Cat. No. P-T142-133

ImpurityTofacitinib Impurity 89Cat. No. P-T142-134

ImpurityTofacitinib Impurity 90Cat. No. P-T142-135

ImpurityTofacitinib Impurity 91Cat. No. P-T142-136CAS 477600-73-0

ImpurityTofacitinib Impurity 92Cat. No. P-T142-137

ImpurityTofacitinib Impurity 93Cat. No. P-T142-138CAS 2102039-99-4

ImpurityTofacitinib Impurity 94Cat. No. P-T142-139

ImpurityTofacitinib Impurity 95Cat. No. P-T142-140

ImpurityTofacitinib Impurity 96Cat. No. P-T142-141

ImpurityTofacitinib Impurity 97Cat. No. P-T142-142CAS 2796191-92-7

Impurity(3S,4S)-Tofacitinib CitrateCat. No. P-T142-143CAS 2174011-55-1

ImpurityTofacitinib Amide ImpurityCat. No. P-T142-147CAS 1675248-19-7

Impurity(3S,4S)-Descyanoacetyl TofacitinibCat. No. P-T142-148CAS 1260614-73-0

Impurity(3S,4S)-1-Benzyl Descyanoacetyl TofacitinibCat. No. P-T142-150CAS 1252883-90-1

Impurity4,5-Dehydro TofacitinibCat. No. P-T142-151CAS 2504210-31-3

Impurity2-Chloro TofacitinibCat. No. P-T142-153CAS 1616761-00-2

Impurity2-Chloro Tofacitinib Impurity 136Cat. No. P-T142-154

ImpurityTofacitinib Acetyl ImpurityCat. No. P-T142-157CAS 477600-76-3

ImpurityTofacitinib N-hydroxy ImpurityCat. No. P-T142-158

ImpurityTofacitinib N-oxideCat. No. P-T142-159CAS 2028267-73-2

ImpurityTofacitinib N-pyrrolopyrimidine ImpurityCat. No. P-T142-160CAS 2504210-38-0

ImpurityTofacitinib Impurity 98Cat. No. P-T142-161

ImpurityTofacitinib Impurity 100Cat. No. P-T142-163

ImpurityTofacitinib Impurity 101Cat. No. P-T142-164

ImpurityTofacitinib Impurity 102Cat. No. P-T142-165

ImpurityTofacitinib Impurity 103Cat. No. P-T142-166

ImpurityTofacitinib Impurity 104Cat. No. P-T142-167

ImpurityTofacitinib Impurity 105Cat. No. P-T142-168

ImpurityTofacitinib Impurity 106Cat. No. P-T142-169

ImpurityTofacitinib Impurity 108Cat. No. P-T142-172

ImpurityTofacitinib Impurity 109Cat. No. P-T142-173CAS 1640972-35-5

ImpurityTofacitinib Impurity 111 DihydrochlorideCat. No. P-T142-175CAS 2640342-78-3

ImpurityTofacitinib Impurity 112Cat. No. P-T142-176

ImpurityTofacitinib Impurity 113Cat. No. P-T142-177

ImpurityTofacitinib Impurity 114 HydrochlorideCat. No. P-T142-178CAS 1206824-85-2

ImpurityTofacitinib Impurity 115Cat. No. P-T142-179

ImpurityTofacitinib Impurity 118Cat. No. P-T142-182

ImpurityTofacitinib Impurity 120Cat. No. P-T142-184

ImpurityTofacitinib Impurity 122Cat. No. P-T142-186

ImpurityTofacitinib Impurity 124Cat. No. P-T142-188

ImpurityTofacitinib Impurity 125Cat. No. P-T142-190

ImpurityTofacitinib Impurity 126Cat. No. P-T142-191

ImpurityTofacitinib Impurity 127Cat. No. P-T142-192

ImpurityTofacitinib Impurity 128Cat. No. P-T142-193

ImpurityTofacitinib Impurity 129Cat. No. P-T142-194

ImpurityTofacitinib Impurity 134 Di-p-toluoyl-D-tartrate (rac-trans)Cat. No. P-T142-199

ImpurityTofacitinib Impurity 135Cat. No. P-T142-200

ImpurityTofacitinib Impurity 136Cat. No. P-T142-201CAS 2097982-05-1

ImpurityTofacitinib Impurity 137Cat. No. P-T142-203

ImpurityTofacitinib Impurity 138Cat. No. P-T142-204

ImpurityTofacitinib Impurity 139Cat. No. P-T142-205

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