Active ingredientTofacitinibCat. No. P-T142-001CAS 477600-75-2
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Nitrosamine · Tofacitinib family
Pharmaceutical analytical standardN-Nitroso Tofacitinib Impurity 5
Synonyms: N-[(3R,4R)-1-(2-Cyanoacetyl)-4-methylpiperidin-3-yl]-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide
- Cat. No.
- P-T142-011
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C15H17N7O2
- Molecular weight
- 327.35 g/mol
- Category
- Nitrosamine
Family: Tofacitinib
A Janus kinase (JAK) inhibitor in tablets, the first approved for rheumatoid arthritis (United States, 2012) and later for other inflammatory diseases. It switches off, from inside the cells, the signals that drive inflammation.
Did you know?Janus kinases are named after Janus, the two-faced Roman god, because they have two almost identical halves: an active one and one that regulates it.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Tofacitinib family
Active ingredientTofacitinibCat. No. P-T142-001CAS 477600-75-2
Active ingredientTofacitinib CitrateCat. No. P-T142-002CAS 540737-29-9
Isotopically labelledN-Nitroso N2-Nitroso Tofacitinib Impurity 9-d3Cat. No. P-T142-003
Isotopically labelledTofacitinib Impurity 21-d3Cat. No. P-T142-004
Isotopically labelledTofacitinib-d3 CitrateCat. No. P-T142-005CAS 2701680-77-3
NitrosamineN-Nitroso TofacitinibCat. No. P-T142-006
NitrosamineN-Nitroso Tofacitinib Impurity 1Cat. No. P-T142-007
NitrosamineN-Nitroso Tofacitinib Impurity 2Cat. No. P-T142-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.