Family · Pharmaceutical analytical standards
Vigabatrin
An antiepileptic that irreversibly blocks GABA transaminase, the enzyme that breaks down GABA, so raising levels of this neurotransmitter in the brain. Approved in the United Kingdom in 1989 and in the United States in 2009, it is used for infantile spasms and epilepsies resistant to other medicines. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards, nitrosamines and other impurities.
Did you know?It was purpose-built to switch the enzyme off for good: it is a copy of GABA with an extra vinyl group, hence the name gamma-vinyl-GABA, and of its two mirror-image forms only one is active.
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EDQM standards 4
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
