Active ingredientEvocalcetCat. No. P-E144-001CAS 870964-67-3
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Impurity or related compound · Evocalcet family
Pharmaceutical analytical standard1-(1-Naphthyl)ethanol
Synonyms: 1-naphthalen-1-ylethanol, Naphthylethanol, Cinacalcet Impurity 59, alpha-Methyl-1-naphthalenemethanol, NSC 70018, Ethanol, 1-(1-naphthyl), alpha-NAPHTHYL METHYL CARBINOL
- Cat. No.
- P-E144-005
- CAS
- 1517-72-2
- Alternative CAS
- 57605-95-5 (alternative CAS, same compound)
- Formula
- C12H12O
- Molecular weight
- 172.23 g/mol
- Category
- Impurity or related compound
Family: Evocalcet
An oral calcimimetic discovered in Japan and approved there in March 2018 for secondary hyperparathyroidism in patients on dialysis: it reduces the production of parathyroid hormone by the parathyroid glands.
Did you know?'Calcimimetic' means 'calcium-mimicking': the drug acts on the calcium receptors of the parathyroid glands and tricks them, as if there were more calcium in the blood, so they release less parathyroid hormone.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Evocalcet family
Active ingredientEvocalcetCat. No. P-E144-001CAS 870964-67-3
Isotopically labelledEvocalcet-d4Cat. No. P-E144-002
NitrosamineN-Nitroso EvocalcetCat. No. P-E144-003CAS 3051508-93-8
Impurity1,2-Bis(4-bromophenyl)hydrazineCat. No. P-E144-004CAS 19717-43-2
ImpurityEvocalcet Impurity 1Cat. No. P-E144-006CAS 946113-79-7
Impurity2-(Naphthalen-1-yl)propanalCat. No. P-E144-007CAS 52417-52-4
Impurity4-Bromophenylacetic acidCat. No. P-E144-008CAS 1878-68-8
ImpurityEvocalcet Impurity 2Cat. No. P-E144-009CAS 64704-10-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.