Active ingredientPomalidomideCat. No. P-P155-001CAS 19171-19-8
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Impurity or related compound · Pomalidomide family
Pharmaceutical analytical standard1,2-Benzenedicarboxylic acid, 3-amino-, hydrochloride
Synonyms: Pomalidomide Impurity 22 HCl, Pomalidomide Impurity 22 Hydrochloride, Phthalic acid, 3-amino-, hydrochloride, Phthalic acid, hydrochloride
- Cat. No.
- P-P155-009
- CAS
- 6946-22-1
- Alternative CAS
- 5434-20-8 (free base)
- 857040-74-5 (free base)
- 14438-56-3 (sodium salt)
- 426837-11-8 (hydrate)
- 1852533-96-0 (hydrate)
- Formula
- C8H7NO4·HCl
- Molecular weight
- 217.61 g/mol
- Category
- Impurity or related compound
Family: Pomalidomide
An immunomodulatory drug derived from thalidomide, approved in 2013 in the United States and Europe for relapsed or refractory multiple myeloma: it is the third drug in its class, after thalidomide and lenalidomide.
Did you know?It works as a kind of 'molecular glue': it binds the protein cereblon and makes it tag two transcription factors, Ikaros and Aiolos, for destruction.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Pomalidomide family
Active ingredientPomalidomideCat. No. P-P155-001CAS 19171-19-8
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Isotopically labelledPomalidomide-d5Cat. No. P-P155-004CAS 1377838-49-7
Isotopically labelledS-Pomalidomide-13C5-15NCat. No. P-P155-005
NitrosamineN-Nitroso PomalidomideCat. No. P-P155-006
Impurity(R)-PomalidomideCat. No. P-P155-007CAS 202271-90-7
Impurity(S)-PomalidomideCat. No. P-P155-008CAS 202271-89-4
ImpurityPomalidomide Impurity FCat. No. P-P155-010CAS 191732-76-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.